Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
نویسندگان
چکیده
منابع مشابه
Colworth, United Kingdom as an in vitro alternative to the in vivo Draize rabbit eye test method for the assessment of eye irritation
The IRE test was developed by Burton and his colleagues at Unilever Research Laboratory, Colworth, United Kingdom as an in vitro alternative to the in vivo Draize rabbit eye test method for the assessment of eye irritation (Burton et al. 1981). In the IRE test method, liquid test substances are spread using a syringe and solids are pulverized and applied as a powder over the corneas of enucleat...
متن کاملDraize Eye Irritancy Test Rabbits
Household products, shampoos, pesticides, weed killers, even riot control gases, are just some of the products tested for irritancy in the eyes of conscious rabbits. The Draize test, introduced in 1944, is cruelly simple. The substance under test is sprayed or instilled into one eye of an albino rabbit. Generally no pain relief is given and the test often proceeds for 7 days during which the co...
متن کاملThe Isolated Chicken Eye test to replace the Draize test in rabbits.
In 1944, Draize et al., published a paper entitled "Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes". The Organization for Economic Co-operation and Development published their first guideline on eye irritation in 1981, using rabbits. In the early eighties the development of alternative non-animal tests to replace the Draize eye ...
متن کاملAnalysis of Draize Eye Irritation Testing and its Prediction by Mining Publicly Available 2008–2014 REACH Data
Public data from ECHA online dossiers on 9,801 substances encompassing 326,749 experimental key studies and additional information on classification and labeling were made computable. Eye irritation hazard, for which the rabbit Draize eye test still represents the reference method, was analyzed. Dossiers contained 9,782 Draize eye studies on 3,420 unique substances, indicating frequent retestin...
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The problem of eye detection in face images is very important for a large number of applications ranging from face recognition to gaze tracking. In this paper we propose a new algorithm for eyes detection. First, the face region is extracted from the image by skin-color information. Second, horizontal projection in image is used to approximate region of the eye be obtained . At last, the eye ce...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-33118-2